MacInnis is a surname. Notable people with the surname include:
Ai Hua (born Charlotte MacInnis in 1981), American television presenter active in China Al MacInnis (born 1963), Canadian hockey defenseman Alison MacInnis (born 1980), American actress Angus MacInnis (1884–1964), Canadian politician David Macinnis Gill (born 1963), American author Donald MacInnis (1918–2007), Canadian politician Gordon MacInnis (born 1945), Canadian businessman and politician Grace MacInnis (1905–1991), Canadian politician and feminist Joseph B. MacInnis (born 1937), Canadian explorer, the first scientist to dive under the North Pole Lloyd MacInnis (1917–1965), Canadian radio host and television presenter Malcolm MacInnis (1933–2023), Canadian politician William H. MacInnis (1861-?), American politician
See also MacInnis Lake, a lake of Cape Breton Regional Municipality, Nova Scotia, Canada McInnes MacInnes