Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.
The TECR gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long chain fatty acids and very long chain fatty acids consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.
Clinical relevance Mutations in this gene have been shown to cause non-syndromic intellectual disability.
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