Chronic allograft nephropathy (CAN) is a kidney disorder which is the leading cause of kidney transplant failure, occurring months to years after the transplant.
Symptoms and signs CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.
Pathology The histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis.
Diagnosis CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.
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