Mazzantini is an Italian surname. Notable people with the surname include:
Andrea Mazzantini (born 1968), Italian footballer Carlo Mazzantini (1925–2006), Italian writer Elena Mazzantini (born 1874), Italian actress known as Daisy Sylvan Giselda Volodi (born Giselda Mazzantini, 1959), Italian actress Leonardo Mazzantini (born 1953), Italian racing cyclist Margaret Mazzantini (born 1961), Italian writer and actress Matteo Mazzantini (born 1976), Italian rugby union player