CW 27 may refer to:
U.S. television stations affiliated with The CW Current WFXR, on DT2 in Roanoke, Virginia WKYT-TV, on DT2 in Lexington, Kentucky WLOV-TV in West Point, Mississippi
Former KREN-TV in Reno, Nevada (2006 to 2009) KWBH-LD in Rapid City, South Dakota (2006 to 2017) WGNT in Portsmouth, Virginia (2006 to 2024)
Other uses CW-27 Caravan, a 1940s American all-wood military transport aircraft (8948) 1997 CW27, a main-belt minor planet