Wemple is a surname of Dutch origin. Notable people with the surname include:

Don Wemple (1917–1944), American football player Edward Wemple (1843–1920), American businessman and politician Erik Wemple (born 1964), American editor William Wemple (lawyer, born 1912) (1912–2002), American lawyer William W. Wemple (1862–1933), New York politician William W. Wemple, Jr. (1898–1972), New York politician

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