Shepperson is a surname. Notable people with the surname include:
Lisa Shepperson (born 1975), Republican member of the Wyoming House of Representatives, representing the 58th district since 2007 Sir Ernest Shepperson, 1st Baronet (1874–1949), Conservative Party politician in the United Kingdom Alec Shepperson (born 1936), English amateur golfer Carrie Still Shepperson (1869–1927), American educator George "Sam" Shepperson, English Africanist and historian Claude Allin Shepperson, (1867–1921) a British artist and illustrator John D. Shepperson, (1851–1921) an American politician