Powderhorn may refer to the following in the United States:
Colorado Powderhorn Resort, a ski area Powderhorn Wilderness, an area in Hinsdale and Gunnison counties Powderhorn, Colorado, an unincorporated community
Minnesota Powderhorn, Minneapolis, a community Powderhorn Park, Minneapolis, a neighborhood Powderhorn Park (urban park) in the Minneapolis neighborhood of the same name
See also Big Powderhorn Mountain Powder Horn (disambiguation) Powderhorn Lake (disambiguation)