Maffeis is an Italian surname derived from the given name Maffeo (an archaic form for 'Matthew'). Notable people with the surname include:
Agnese Maffeis (born 1965), Italian discus thrower and shot putter Angela Maffeis (born 1996), Italian cyclist Ivan Maffeis (born 1963), Italian Roman Catholic prelate
See also Maffei (surname) Maffey