William Gascoigne may refer to:
Sir William Gascoigne (c. 1350–1419), Chief Justice of England William Gascoigne (MP for Yorkshire), in 1421 MP for Yorkshire William Gascoigne (MP died 1423), MP for Bridgwater Sir William Gascoigne (died 1540), MP for Bedfordshire William Gascoigne (scientist) (1612–1644), English scientific instrument maker Sir William Julius Gascoigne (1844–1926), British Army general