Heyse is a surname of German origin. Notable people with the name include:
Johann Christian August Heyse (17641829), German grammarian and lexicographer, father of Karl Karl Wilhelm Ludwig Heyse (17971855), German philologist, father of Paul Paul Heyse (18301914), German writer and translator Ulrich Heyse (19061970), German U-boat commander in World War II
See also Genzsch & Heyse, A.G., a German type foundry established in Hamburg