House of Mystery is a series of comics.
House of Mystery may also refer to:
Film The House of Mystery (1923 film), a French silent serial film The House of Mystery (1933 film), a French crime film The House of Mystery (1934 film), an American pre-code mystery horror film directed by William Nigh House of Mystery, American alternative title of At the Villa Rosa House of Mystery (1961 film), a British supernatural mystery film
Literature The House of Mystery, an 1898 novel by Richard Marsh The House of Mystery, a 1906 play by Langdon McCormick and a novelization of the play by Grace Miller White The House of Mystery, a 1910 novel by Will Irwin House of Mystery (Vertigo), an American occult and horror-themed comic book anthology series
Radio The House of Mystery (radio series) (1945–1949), an American radio dramatic anthology