P38 or P-38 may refer to:
Biology and medicine Multisynthetase complex auxiliary component p38 p38 mitogen-activated protein kinases RPP38, ribonuclease P protein subunit p38
Military , a P-class sloop of the Royal Navy , a submarine of the Royal Navy Lockheed P-38 Lightning, an American fighter aircraft P-38 can opener, issued by the United States Armed Forces Walther P38, a pistol
Other uses Mitchell Wing P-38, an American ultralight aircraft Papyrus 38, a biblical manuscript Phosphorus-38, an isotope of phosphorus Range Rover (P38A), a SUV Porax-38, a starfighter from the Star Wars fictional universe