Gambrell is a surname. Notable people with the surname include:
Billy Gambrell (born 1941), American football player David H. Gambrell (1929–2021), American politician Dorothy Gambrell (), American cartoonist who writes and draws the online comic strip Cat and Girl Dylan Gambrell (born 1996), American ice hockey player James Bruton Gambrell (1841–1921), American Baptist minister Jamey Gambrell (1954–2020), American translator of Russian literature, and expert in modern art Marilyn Gambrell (), American parole officer turned teacher Michael Gambrell (born 1958), American politician
See also Gambrill, another surname