Leo P. O'Brien (July 20, 1893 – March 25, 1968) was a member of the Wisconsin State Senate from the 2nd District.

Biography O'Brien was born on July 20, 1893, in Fond du Lac, Wisconsin. He attended the University of Wisconsin-Madison, Marquette University and St. Norbert College.Wisconsin Blue Book, 1964, Biographical Sketch of Leo O'Brien, p. 22. During World War I and World War II, he served with the United States Navy. He died in 1968 of a heart attack. "Ex-State Senator, Leo P. O'Brien, Dies", Madison Wisconsin State Journal, Tuesday, March 26, 1968, Madison, Wisconsin, United States Of America

Political career O'Brien was a member of the Senate from 1953 to 1964. He was a Republican.

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