Southern Discomfort may refer to:
Southern Discomfort (Rita Mae Brown novel), a novel released in 1982 by Rita Mae Brown Southern Discomfort (Eyehategod album), an album released in 2000 by sludge metal band Eyehategod Southern Discomfort (Rehab album), is an album released in 2000 by rock band Rehab Southern Discomfort (Fabian Society pamphlets), a series of pamphlets that examined attitudes to the British Labour Party in the south of England Southern Discomfort Roller Derby, a men's roller derby league based in London "Southern Discomfort", an episode of the seventh season of The Real Housewives of Atlanta, an American reality television series The Mask: Southern Discomfort, a 1996 comic book limited series published by Dark Horse Comics