The 1910 season was the fifth season of the Columbus Panhandles. The team played in the Ohio League posted a 3–2–2 record.
Schedule Game Date Opponent Result 1 October 9, 1910 Columbus Northerns W 10–0 2 October 16, 1910 Cincinnati Celts T 0–0 3 October 23, 1910 at Akron Tigers L 40–0 4 October 30, 1910 Cleveland Lyceum L 12–6 5 November 6, 1910 Columbus Barracks W 24–0 6 November 13, 1910 Akron Tigers W 23–10 7 November 24, 1910 at Dayton Oakwoods T 5–5
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