Francis Leke may refer to:
Francis Leke (MP) (died 1580), English politician Francis Leke, 1st Earl of Scarsdale (1581–1655) Sir Francis Leke, 1st Baronet (1627–1679), MP for Nottinghamshire Sir Francis Leke, 2nd Baronet (died 1681) of the Leke baronets
See also Leke (disambiguation)