Puiu () is both a Romanian masculine given name and a surname. Notable people with the name include:
Cristi Puiu (born 1967), Romanian film director and screenwriter Visarion Puiu (1879–1964), Romanian Orthodox bishop Puiu Dumitrescu, private secretary to King Carol II Puiu Hașotti (born 1953), Romanian politician Puiu Manu (born 1928), Romanian graphic designer and comic book creator See also Puiești (disambiguation)