San Isidro District may refer to:
Peru San Isidro District, Lima, a district of the Lima province Costa Rica San Isidro District, Alajuela, in Alajuela (canton), Alajuela province San Isidro District, Atenas, in Atenas (canton), Alajuela province San Isidro District, El Guarco, in El Guarco (canton), Cartago province San Isidro District, Grecia, in Grecia (canton), Alajuela province San Isidro District, León Cortés, in León Cortés (canton), San José province San Isidro District, Montes de Oro, in Montes de Oro (canton), Puntarenas province San Isidro District, San Isidro, in San Isidro (canton), Heredia province San Isidro District, San Ramón, in San Ramón (canton), Alajuela province San Isidro, Vázquez de Coronado, in Vázquez de Coronado (canton), San José province San Isidro del El General District, in Pérez Zeledón (canton), San José province