James Agnew (1815–1901) was Premier of Tasmania.

James Agnew may also refer to:

James Agnew (British Army officer) (1719–1777) Sir James Agnew, 4th Baronet (c. 1660–1735) James E. Agnew (1891–1956), American politician in Boston, Massachusetts Jim Agnew (born 1966), ice hockey player

See also Agnew (disambiguation)