Fritsche is a German surname. Like Fritsch, Fritzsch and Fritzsche, it is a patronymic derived from Friedrich. Notable people with the surname include:
Claudia Fritsche (born 1952), Liechtenstein diplomat Dan Fritsche (born 1985), American ice hockey player Hans Fritsche (officer) (1909–1993), German Wehrmacht officer Helmut Fritsche (1932–2008), German agronomist and politician John Fritsche Jr. (born 1991), American ice hockey player John Fritsche Sr. (born 1966), American ice hockey player
See also Frič, Czechized variation of the name