Thomas Preston may refer to:

Politicians Thomas Preston (MP for Derby), see Derby Thomas Preston (died 1604), MP for Knaresborough Thomas Preston of Gretton, MP for Northampton Thomas Preston (MP for Newcastle-under-Lyme), in 1437 MP for Newcastle-under-Lyme Thomas Preston, in 1452 MP for Wallingford Thomas Preston (of Holker, elder) (1600–1679), English MP for Lancashire Thomas Preston (of Holker, younger) (1647–1697), English MP for Lancaster Thomas Hiram Preston (1855–1925), Ontario journalist and political figure Thomas Hildebrand Preston (1886–1976), British diplomat

Religion Thomas Preston (monk) (1563–1640), English Benedictine monk Thomas Scott Preston (1824–1891), Roman Catholic Vicar General of New York

Others Thomas Preston (composer) (died c. 1563), English composer Thomas Preston (footballer) (1893–1971), Scottish footballer (Airdrieonians) Thomas Preston (writer) (1537–1598), master of Trinity Hall, Cambridge and possible author of King Cambyses Thomas Preston, 1st Viscount Tara (1585–1655), who fought on the side of Confederation in the Irish Confederate Wars (1642–1649) Thomas Preston (British Army officer), involved in the Boston Massacre in 1770 Thomas Austin Preston, Jr. (1928–2012), poker player also known as Amarillo Slim Thomas Preston (scientist) (1860–1900), Irish scientist Thomas J. Preston Jr. (1862–1955), professor of archeology at Princeton University Tommy Preston (1932–2015), Scottish footballer (Hibernian) Tom Preston-Werner (born 1979), American entrepreneur (GitHub)