Buono is an Italian surname. Notable people with the surname include:
Angelo Buono Jr. (1934–2002), American serial killer Barbara Buono (born 1953), American Democratic Party politician Cara Buono (born 1971), American actress Cosmo Buono, American pianist John L. Buono (born 1943), American Republican Party politician Victor Buono (1938–1982), American actor and comic Wally Buono (born 1950), Canadian head coach, general manager and alternate governor