Etrolizumab (rhuMAb Beta7) is a biopharmaceutical drug candidate being developed for the treatment of ulcerative colitis and Crohn's disease. It is a humanized monoclonal antibody against the β7 subunit of integrins α4β7 and αEβ7.Adis Insight Etrolizumab Latest Information Update: 16 Dec 2015 Etrolizumab was developed by GenentechUK Medicines Information. etrolizumab at UKMI Page accessed May 10, 2016 by engineering the FIB504 antibody to include human IgGl-heavy chain and κ-light chain frameworks; it is manufactured in CHO cells. For the FIB504 mAb, see Andrew DP et al. Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. as referenced in paragraph 146 of the PCT application.
As of 2016, it was in phase III studies for induction and maintenance therapy in people with ulcerative colitis and Crohn's. According to data of one meta-analysis efficacy of Etrolizumab is comparable with conventional therapies such as Infliximab with less adverse events.
Phase III clinical trials produced mixed results; and, on October 14, 2020, Hoffmann-La Roche, the parent company of Genentech, abandoned further efforts to develop etrolizumab for ulcerative colitis, but continued development for Crohn's disease, until disappointing trial results led to this being abandoned too in February 2022.
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