Maria Sharapova defeated Kim Clijsters in the final, 7–5, 7–5 to win the singles tennis title at the 2006 Southern California Open.
Mary Pierce was the defending champion, but lost in the quarterfinals to Sharapova.
Seeds The top eight seeds received a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
External links ITF tournament details