Sleightholme may refer to
Places Sleightholme, a hamlet in County Durham (formerly in the North Riding of Yorkshire), England Sleightholme Dale, a valley in the North York Moors, North Yorkshire, England
People John Sleightholme, English football investor Jon Sleightholme (born 1972), English rugby union footballer Ollie Sleightholme (born 2000), English rugby union footballer