Polhemus may refer to:

Gianni Polhemus, American road bike racer Gretchen Polhemus (born 1965), former Miss USA and second runner-up to Miss Universe 1989 John T. Polhemus (1929–2013), American entomologist Mark Polhemus (1860–1923), Major League Baseball player Ted Polhemus (born 1947), American anthropologist, writer, and photographer who lives and works on England's south coast

See also James S. Polhemus House, house in southeast Portland, Oregon listed on the National Register of Historic Places Polhemus & Coffin, New York-based architectural firm formed by Henry M. Polhemus and Lewis Augustus Coffin Polhemus Memorial Clinic in Brooklyn, New York, built in 1897 as an extension of a hospital for the poor