Letha may refer to:

Letha (character) (Hellen Feliciano), a supervillain in the Marvel Comics Universe Letha, Idaho, an unincorporated town in Gem County, Idaho, United States Letha Dawson Scanzoni (born 1935), independent scholar, author, and editor Letha Wilson (born 1976), American artist Letha Raney Intermediate School, a middle school in Corona, California

See also Austroassiminea letha, a species of minute salt marsh snail Thecla letha, a small butterfly found in India