Tartaglione (, meaning "stutterer") is an Italian surname. Notable people with this surname include:
Antonio Tartaglione (born 1998), Italian footballer Christine Tartaglione (born 1960), Democratic member of the Pennsylvania State Senate for the 2nd District John Tartaglione (1921–2003), American comic book artist Margaret Tartaglione (1933–2019), Philadelphia City Commissioner through January 2012, mother of Christine Tartaglione Nicholas Tartaglione (born 1967), American former police officer and cell mate of Jeffrey Epstein