Buddleja scordioides is endemic to central Arizona, southeastern New Mexico, southwestern Texas, and the Chihuahua Desert of Mexico, growing amidst xeric thorn-scrub on alkaline soils at elevations of . The species was first named and described by Kunth in 1818.Kunth, in Humboldt, Bonpland, and Kunth. (1818). Nov. gen. sp., ed. fol. 2:278 ed. quar. 2:345, t183, 1818.

Description Buddleja scordioides is a weedy dioecious shrub tall with shredding bark. The young branches are subquadrangular and tomentose, bearing small oblong to linear membranaceous grayish-green leaves long by wide, rugose above, and tomentose on both surfaces. The sage-scented lemon-yellow leafy inflorescences are long, comprising 3 – 15 pairs of sessile clusters, each with 15 – 20 flowers, the corollas 1.5 – 2 mm long. Ploidy: 2n = 38.

Cultivation The species is not known to be in cultivation.

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