Pyridine-2-carbaldehyde, also called 2-formylpyridine, is an organic compound with the formula NC5H4CHO. It is one of three isomeric pyridinaldehydes. The other isomers are pyridine-3-carboxaldehyde and pyridine-4-carboxaldehyde.
Pyridine-2-carbaldehyde is a colorless oily liquid with a distinctive odor. Older samples are often brown-colored owing to impurities. It serves as a precursor to other compounds of interest in coordination chemistry and pharmaceuticals. Pyridine aldehydes are typically prepared by oxidation of the hydroxymethyl- or methylpyridines.
Reactions and uses The drug pralidoxime can be produced from 2-formylpyridine.
The aldehyde functional group is subject to nucleophilic attack, specifically by amines to form Schiff bases, which serve as bidentate ligands. Iminopyridine complexes can be remarkably robust.
Pyridine-2-carbaldehyde is used in the synthesis of ARN2966 [102212-26-0],Bijan Almassian, Martin J. Sadowski, & Xu Kevin Lin, US8658677 (2014 to New York University NYU, Aria Neurosciences Inc). one of the syntheses of Mefloquine,Guenther North Caldwell N.J. Us Grethe, Toomas Bloomfield N.J. Us Mitt, DE2806909 (1988 to F. Hoffmann-La Roche & Co. Ag, Basel, Ch). RWJ-22757 (Mcn-5195) [103729-18-6],Richard J. Carmosin & John R. Carson, US4582836 (1986 to Janssen Pharmaceuticals Inc). & in one of the syntheses of Carbinoxamine.A. P. Swain, US2800485 (1957).王启发, 程青芳, 刘洲, CN104774174 (2017 to 淮海工学院).
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