Kyprianou (Greek: Κυπριανού) is a Greek-language surname that may refer to the following notable people:
Andreas Kyprianou (born 1988), Cypriot football striker Andros Kyprianou (born 1955), Greek Cypriot politician, General Secretary of AKEL Hector Kyprianou (born 2001), English-born Cypriot footballer Lycourgos Kyprianou, Cypriot businessman, former chairman of GlobalSoft and AremisSoft Corp Markos Kyprianou (born 1960), Cypriot politician, Minister of Foreign Affairs until 2011 Spyros Kyprianou (1932–2002), Cypriot politician, 2nd President of the Republic of Cyprus from 1977 to 1988
See also Spyros Kyprianou Athletic Center, Cyprus Spyrou Kyprianou Avenue, Nicosia, Cyprus