Spyrou Kyprianou Avenue (, ), is an important avenue located in the centre of Nicosia, Cyprus formerly known as Santa Rosa Avenue.
The Avenue was named after Spyros Kyprianou (), a former president of the Republic of Cyprus. It intersects Makariou Anevue and it hosts a number of highrises, banks and financial and corporate service companies.
The Headquarters of the Electricity Authority of Cyprus (), lie on the left-hand side of the Avenue and behind Stasikratous Street.
The avenue is one of the key nightlife districts in Nicosia, having numerous cafeterias, bars, clubs and restaurants
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