K22 may refer to:
Roads K-22 (Kansas highway) K-22 (1926–1931 Kansas highway) K-22 (1930–1938 Kansas highway)
Vehicles Changhe Freedom K22, a Chinese pickup truck , a K-class submarine of the Royal Navy , a corvette of the Swedish Navy
Other uses K-22 trailer, part of the American SCR-270 radar system Big Sandy Regional Airport, in Martin County, Kentucky Smith & Wesson Model K-22, a revolver Symphony No. 5 (Mozart), K. 22, by Wolfgang Amadeus Mozart The k22 family of uniform polytopes Honda K Engines