Spironema may refer to:
Animals: Spironema (gastropod), Spironema Meek, 1864 – a genus of Cretaceous sea snails
Plants: Spironema Raf. – sometimes considered a synonym of Cassytha L. (Lauraceae) Spironema Lindl. nom. illeg. hom. – a synonym of Callisia Loefl. (Commelinaceae) Spironema Hochst. nom. illeg. hom. – a synonym of Clerodendrum L. (Lamiaceae)
Protists: Spironema (flagellate), Spironema Klebs, 1893 nom. illeg. hom. – a synonym of Spironematella P. C. Silva, a genus of flagellate protists in the family Spironemidae.
Spirochaetes: Spironema Vuillemin, 1905 – a synonym of Treponema Schaudinn, 1905
Microsporidia: Spironema Léger & Hesse, 1924 – a synonym of Toxoglugea Léger & Hesse, 1924