Fluorocitric acid is an organic compound with the chemical formula . It is a fluorinated carboxylic acid derived from citric acid by substitution of one methylene hydrogen by a fluorine atom. The appropriate anion is called fluorocitrate. Fluorocitrate is formed in two steps from fluoroacetate. Fluoroacetate is first converted to fluoroacetyl-CoA by acetyl-CoA synthetase in the mitochondria. Then fluoroacetyl-CoA condenses with oxaloacetate to form fluorocitrate. This step is catalyzed by citrate synthase. Fluorocitrate is a metabolite of fluoroacetic acid and is very toxic because it is not processable using aconitase in the citrate cycle (where fluorocitrate takes place of citrate as the substrate). The enzyme is inhibited and the cycle stops working.
See also Chlorocitric acid Citric acid Citrate cycle Fluoroacetic acid Fluorooleic acid Isocitric acid
References
External links PubChem: Fluorocitrate Human Metabolome Database (HMDB): Fluorocitric acid The Chemical and Biochemical Properties of Fluorocitric Acid Pdf