V12 or V-12 may refer to:
Aircraft Mil V-12, a Soviet heavy lift helicopter Pilatus OV-12, a planned American military utility aircraft Rockwell XFV-12, an American experimental aircraft project Škoda-Kauba V12, a Czechoslovak experimental aircraft project Vultee V-12, an American-designed bomber
Automobiles Cadillac V-12, an American car Lagonda V12, a British car
Other uses V12 engine, an engine with twelve cylinders Simpiwe Vetyeka (born 1980), South African boxer V-12 Navy College Training Program, of the United States Navy during World War II Victor V12, a calculator V12, a grade in bouldering V12, a personal history of certain other diseases, in the ICD-9 V codes