Hydrangenol is a dihydroisocoumarin. It can be found in Hydrangea macrophylla, as well as its 8-O-glucoside. (−)-Hydrangenol 4′-O-glucoside and (+)-hydrangenol 4′-O-glucoside can be found in Hydrangeae Dulcis Folium, the processed leaves of H. macrophylla var. thunbergii. It has been shown to suppress production of several inflammatory signalling molecules including MMP-1, MMP-3, COX-2 and IL-6.Myung DB, Han HS, Shin JS, Park JY, Hwang HJ, Kim HJ, Ahn HS, Lee SH, Lee KT. Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice. Nutrients. 2019 Oct 2;11(10):2354.
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