Polizzi is an Italian surname. Notable people with the surname include:
Alex Polizzi (born 1971), British television personality Alfred Polizzi (1900–1975), American mobster Frank Polizzi (1936–2001), American mobster Nicole "Snooki" Polizzi (born 1987), American television personality Olga Polizzi, British hotelier Rick Polizzi (born 1958), American television producer and writer