Duffie or Duffié is a surname. Notable people with the surname include:
Alfred N. Duffié (1833–1880), French-American soldier and diplomat who served in the Crimean War and the American Civil War Ann Davison Duffie (1923–2018), American civic leader and musician Darrell Duffie (born 1954), Canadian economist Grace Duffie Boylan (1861–1935), American writer John Duffie (born 1945), former pitcher in Major League Baseball Kieran Duffie (born 1992), professional Football player Marion Davison Duffie (1896–1965), American singer and voice teacher Matt Duffie (born 1990), professional rugby league player Paul Duffie (born 1951), former politician, lawyer and judge in the Canadian province of New Brunswick William R. Duffie (1931–1999), forestry engineer and political figure in New Brunswick, Canada
See also Duffy