House of Secrets may refer to:

Film The House of Secrets (1929 film), a 1929 American mystery film House of Secrets (1936 film), an American film House of Secrets (1956 film), a British film directed by Guy Green House of Secrets, a 1993 American television film directed by Mimi Leder

Literature Comics House of Secrets (DC Comics), several mystery-suspense, anthology comic book series published by DC Comics House of Secrets (Vertigo), an occult and horror-themed comic book series published by Vertigo

Novels The House of Secrets (novel), a 1926 novel by Sydney Horler The House of Secrets, a 1963 novel by Nina Bawden House of Secrets, a 1971 novel by Rosemary Timperley A House of Secrets, a 1991 novel by Patti Davis House of Secrets, a 1994 novel by Jean Saunders, writing as Sally Blake House of Secrets, a 1995 novel by James A. Moore and Kevin Andrew Murphy House of Secrets, a 1996 novel by Beverly Lewis House of Secrets (novel), a 2013 novel by Chris Columbus and Ned Vizzini The House of Secrets, a 2016 novel by Tod Goldberg and Brad Meltzer The House of Secrets, a 2017 novel by Sarra Manning House of Secrets, a 2018 novel by V. C. Andrews

Television "House of Secrets", an episode of Dominick Dunne's Power, Privilege, and Justice "House of Secrets", an episode of House of Anubis "House of Secrets", an episode of Maelstrom

Other uses House of Secrets (album), a 2004 music album by OTEP

See also The House of the Secret, the title of two unrelated novels; the 1910 book by Katharine Tynan and the 1911 book by Claude Farrère The Secret House, a 1917 thriller novel by Edgar Wallace House of Secrets: The Burari Deaths, a 2021 docuseries by Netflix