van Asperen is a Dutch surname meaning "from Asperen". It may refer to:
Aart van Asperen (b. 1956), Dutch television director Bob van Asperen (b. 1947), Dutch harpsichordist Eelco van Asperen (1965–2013), Dutch computer scientist Janneke van Asperen (fl. 2020s), Dutch art historian and museum curator Gerrit Verdooren van Asperen (1757–1824), Dutch naval officer