The initials TPK may refer to:
Arts and entertainment Total party kill, in role-playing games The Paper Kingdom, an unreleased album by My Chemical Romance
Businesses and organisations Tai Ping Koon Restaurant, Hong Kong Te Puni Kōkiri, a New Zealand government department Turun Pallokerho, a Finnish football club
Other uses Code for Tanjung Priok railway station in Jakarta, Indonesia TPK algorithm, in computer science Traditional Phenological Knowledge, in anthropology