Edward O'Donnell may refer to:
Eddie O'Donnell (1887–1920), American race car driver Edward O'Donnell (bootlegger) or Spike O'Donnell (1890–1962), American mobster of Irish descent Edward J. O'Donnell (military) (1907–1991), U.S. Navy rear admiral and commander of Guantanamo Bay Naval Base Edward J. O'Donnell (academic administrator) (1909–1986), President of Marquette University (1948–1962) Edward Joseph O'Donnell (1931–2009), Roman Catholic Bishop of the Diocese of Lafayette, Louisiana