Setzer is a German and Jewish occupational surname. In Middle High German setzen meant to set prices and referred to a market inspector or a tax official. In Yiddish setser referred to a typesetter (German: Schriftsetzer). Notable people with the surname include:

Arlene Setzer, American politician Brian Setzer (born 1959), American guitarist and songwriter Dennis Setzer, American race car driver Franz Xaver Setzer, actually Franz Anton Adolf (1886–1939), Austrian photographer Henry Setzer, American politician Matthew Setzer, American musician, composer, and music technologist Mitchell S. Setzer, American politician

See also Setzer Gabbiani, character in the video game Final Fantasy VI References