Lupien may refer to:
Gilles Lupien (1954–2021), Canadian ice hockey player Tabitha Lupien (born 1988), Canadian actress and competitive dancer Tony Lupien (1917–2004), American baseball player Yannick Lupien (born 1980), Canadian freestyle swimmer Bill Lupien (1941–2021), American business executive in the financial industry Ulysses J. Lupien (1883–1965), American government official and business executive
See also
Saint-Lupien, commune in the Aube department in north-central France