Spahiu is an Albanian surname. Notable people with the surname include:
Albert Spahiu (born 1990), Kosovar-Swiss football striker Avni Spahiu (born 1953), Kosovar diplomat and television director Bedri Spahiu (1908–1998), Albanian politician Bujar Spahiu (born 1976), Albanian Muslim scholar Ekrem Spahiu (born 1960), Albanian politician Gabriel Spahiu (born 1968), Romanian actor of Kosoven descent Kreshnik Spahiu (born 1969), Albanian lawyer and politician Rexhep Spahiu (1923–1993), Albanian football player and coach Sebastjan Spahiu (born 1999), Albanian association football player Xhafer Spahiu (1923–1999), Albanian politician Xhevahir Spahiu (born 1945), Albanian poet
See also Sipahi, Turkish professional cavalrymen