James Little may refer to:
James Little (American politician), Wisconsin State Assemblyman James Little (British politician) (1868–1946), unionist politician in Northern Ireland James Little (physician) (1837–1916), Irish physician James-Little Ecological Reserve Jimmy Little (1937–2012), Australian Aboriginal musician, singer and songwriter Jim Little (businessman) (born 1964), CEO of Ottawa Senators Jimmy Little (carpenter) (born 1976), carpenter, stagehand and TV personality James Little (shepherd) (1834–1921), New Zealand shepherd and sheep breeder James Little (unionist), American labor union leader James Lewis Little (1871–1967), schooner captain and politician in Newfoundland James Little (painter) (born 1952), American painter
See also Allan Little (born 1959), former BBC researcher and reporter