Gaines House or Gaines Farm may refer to:
in the United States (by state then city/town) Ralph Gaines House, Elberton, Georgia, listed on the National Register of Historic Places (NRHP) in Elbert County Benjamin R. Gaines Farm, Burlington, Kentucky, listed on the NRHP in Boone County James Gaines House, Georgetown, Kentucky, listed on the NRHP in Scott County Wingate-Gaines Farm District, Petersburg, Kentucky, listed on the NRHP in Boone County Col. Abner Gaines House, Walton, Kentucky, listed on the NRHP in Boone County McGavock-Gaines House, Franklin, Tennessee, NRHP-listed Craig-Beasley House, also known as Gaines House, listed on the NRHP in Williamson County